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  • KD/KO Validated

IMPDH2 Polyclonal antibody

IMPDH2 Polyclonal Antibody for IF, IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (1)





Cat no : 12948-1-AP


IMP dehydrogenase 2, IMPD 2, IMPD2, IMPDH 2, IMPDH II, IMPDH2

Tested Applications

Positive WB detected inHeLa cells, rat heart tissue, A549 cells, MCF-7 cells, K-562 cells
Positive IP detected inHeLa cells
Positive IHC detected inhuman lung cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:5000-1:50000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12948-1-AP targets IMPDH2 in WB, RIP, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat, zebrafish
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IMPDH2 fusion protein Ag3632
Full Name IMP (inosine monophosphate) dehydrogenase 2
Calculated Molecular Weight 514 aa, 56 kDa
Observed Molecular Weight 56 kDa
GenBank Accession NumberBC012840
Gene Symbol IMPDH2
Gene ID (NCBI) 3615
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270) IMPDH2 is highly enriched in RR(filamentous rods and rings). This antibody may have cross-reaction with IMPDH1 due to the high homology.


Product Specific Protocols
WB protocol for IMPDH2 antibody 12948-1-APDownload protocol
IHC protocol for IMPDH2 antibody 12948-1-APDownload protocol
IF protocol for IMPDH2 antibody 12948-1-APDownload protocol
IP protocol for IMPDH2 antibody 12948-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Mol Cell

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Authors - Eunus S Ali

J Clin Invest

Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.

Authors - Jonathan I Lake

Mol Ther

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Authors - Hailong Ruan
  • KD Validated

Autoimmun Rev

Anti-rods/rings autoantibodies in a patient with pancreatic injury.

Authors - Shingo Katayama

Cancer Lett

Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.

Authors - Shiyu Wang


SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome.

Authors - Michela Zaffagni