Kir6.2 Polyclonal antibody

Kir6.2 Polyclonal Antibody for IF, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF,ELISA

Conjugate

Unconjugated

Cat no : 16920-1-AP

Synonyms

BIR, HHF2, IKATP, KCNJ11, KIR6.2, PHHI, TNDM3



Tested Applications

Positive WB detected inrat heart tissue, HepG2 cells, human heart tissue, rat skeletal muscle tissue
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Product Information

16920-1-AP targets Kir6.2 in WB, IF,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Kir6.2 fusion protein Ag10262
Full Name potassium inwardly-rectifying channel, subfamily J, member 11
Calculated molecular weight 390 aa, 44 kDa
Observed molecular weight 48 kDa
GenBank accession numberBC064497
Gene symbol KCNJ11
Gene ID (NCBI) 3767
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Kir6.2 (also known as BIR or IKATP), encoded by the KCNJ11 gene, is the pore-forming unit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. Kir6.2 is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel. The KCNJ11 gene is located at 11p15.1 and has no intron. Mutations in KCNJ11 are a cause of familial PHHI, an autosomal recessive disorder characterized by unregulated ins secretion. Defects in KCNJ11 may also contribute to autosomal dominant non-ins-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).

Protocols

Product Specific Protocols
WB protocol for Kir6.2 antibody 16920-1-APDownload protocol
IF protocol for Kir6.2 antibody 16920-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols