LGR4 Polyclonal antibody

LGR4 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (1)





Cat no : 20150-1-AP


G protein coupled receptor 48, GPR48, LGR4

Tested Applications

Positive IHC detected inhuman small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Immunohistochemistry (IHC)IHC : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 20150-1-AP is LGR4 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LGR4 fusion protein Ag13695
Full Name leucine-rich repeat-containing G protein-coupled receptor 4
Calculated Molecular Weight 104 kDa
GenBank Accession NumberBC033039
Gene Symbol LGR4
Gene ID (NCBI) 55366
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

LGR4, also known as GPR48, is a membrane of the leucine-rich GPCR family. LGR4 is composed of a large NH2-terminal extracellular domain containing 18 LRRs, the seven membrane-spanning segments, and a COOH-terminal intracellular domain. LGR4 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. It has also been shown that LGR4 regulates cyclic AMP/protein kinase A (PKA) signalling. (PMID: 23756652; 17178856; 24212090)


Product Specific Protocols
IHC protocol for LGR4 antibody 20150-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Cell Biol

LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.

Authors - Pingping Zhu

Mol Ther Oncolytics

Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer.

Authors - Xiaohong Ruan

Cancer Biomark

LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer

Authors - Zhaoyang Zeng

Exp Cell Res

Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway.

Authors - Xuesong Su

In Vitro Cell Dev Biol Anim

SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4

Authors - Sunyu Chen

Cell Death Dis

DNA methylation mediated RSPO2 to promote follicular development in mammals.

Authors - Xiaofeng Zhou