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Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic cell adhesion molecules. LRRTMs are highly localized in the postsynaptic density and play various roles in the formation, maturation, and function of synapses (PMID: 25951919). LRRTM2 acts as a post-synaptic ligand of Neurexins. LRRTM2 regulates excitatory synapse development and function in the vertebrate nervous system (PMID: 20064387).