MFN2 Antibody 20 Publications

Rabbit Polyclonal| Catalog number: 12186-1-AP

Featured Product KD/KO validated

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human heart tissue, human colon cancer tissue, human heart tissue, human kidney tissue

Recommended dilution:
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitofusin 2

Calculated molecular weight:
757aa,86 kDa

Observed molecular weight:
86 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MFN2

Synonyms
CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF, MFN2, Mitofusin 2, Transmembrane GTPase MFN2
Background

MFN2, also named as CPRP1 and KIAA0214, belongs to the mitofusin family. It is an Essential transmembrane GTPase, which mediates mitochondrial fusion. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression of MFN2 induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6).


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