Product Information
17426-1-PBS targets MIER2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | MIER2 fusion protein Ag11491 Predict reactive species |
Full Name | mesoderm induction early response 1, family member 2 |
Calculated Molecular Weight | 545 aa, 60 kDa |
Observed Molecular Weight | 65-70 kDa |
GenBank Accession Number | BC028203 |
Gene Symbol | MIER2 |
Gene ID (NCBI) | 54531 |
RRID | AB_2143931 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q8N344 |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
Mesoderm induction early response 2 (MIER2) is a member of the MIER family of proteins, which is relatively conservative in evolution and includes three members: MIER1, MIER2, and MIER3. The MIER family is known to contribute to histone deacetylase (HDAC) activity and actively participate in histone deacetylation (PMID: 28046085; PMID: 38702028). In renal cell carcinoma, MIER2 represses PGC1A expression by recruiting HDAC1 to deacetylate P53 (PMID: 28046085).