MOG Recombinant antibody

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  WB analysis using 83063-6-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 83063-6-RR (MOG antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

MOG Uni-rAb^TM Recombinant Antibody for WB, ELISA

Cat No. 83063-6-RR

Clone No.250235E1

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat, pig

Applications

Synonyms

MOGIG 2, Myelin-oligodendrocyte glycoprotein

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Tested Applications

• Positive WB detected in: mouse brain tissue, rat brain tissue, pig brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

83063-6-RR targets MOG in applications and shows reactivity with human, mouse, rat, pig samples.

• Tested Reactivity: human, mouse, rat, pig
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: MOG fusion protein Eg2878
• Full Name: myelin oligodendrocyte glycoprotein
• Calculated Molecular Weight: 24 kDa
• Observed Molecular Weight: 25-28 kDa
• GenBank Accession Number: N/A
• Gene Symbol: MOG
• Gene ID (NCBI): 4340
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q16653-1
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Myelin/oligodendrocyte glycoprotein (MOG), a 23~28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.