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MTUS1 Polyclonal antibody

MTUS1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 18791-1-AP

Synonyms

AT2 receptor binding protein, ATBP, ATIP, GK1, KIAA1288, MP44, MTSG1, MTUS1

Validation Data Gallery

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  • Western Blot (WB) analysis of human skeletal muscle tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of human skeletal muscle using 18791-1-AP

    human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse uterus tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of mouse uterus using 18791-1-AP

    mouse uterus tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human skeletal muscle tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of human skeletal muscle using 18791-1-AP

    human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Tested Applications

Positive WB detected inhuman skeletal muscle tissue, mouse uterus tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 18791-1-AP is MTUS1 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MTUS1 fusion protein Ag5605
Full Name mitochondrial tumor suppressor 1
Calculated Molecular Weight 51 kDa, 141 kDa
Observed Molecular Weight 120 kDa, 180 kDa
GenBank Accession NumberBC033842
Gene Symbol MTUS1
Gene ID (NCBI) 57509
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706) The antibody can recognize all the isoforms except isoform 5 (85-90kd). The antibody tested HomoDimer isoforms (110-120/180kd) in Human skeletal muscle.