MX2 Polyclonal antibody, PBS Only

• 

  WB analysis using 13278-1-AP (same clone as 13278-1-PBS)

  Untreated and IFN beta treated THP-1 cell lysates were subjected to SDS PAGE followed by western blot with 13278-1-AP (MX2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13278-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 13278-1-AP (same clone as 13278-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 13278-1-AP (MX2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13278-1-PBS in a different storage buffer formulation.

MX2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 13278-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

p78-related protein, p78 related protein, Myxovirus resistance protein 2, MXB, Interferon-regulated resistance GTP-binding protein MxB

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Product Information

13278-1-PBS targets MX2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag4020

  Product name: Recombinant human MX2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 369-715 aa of BC035293

  Sequence: RLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH

• Full Name: myxovirus (influenza virus) resistance 2 (mouse)
• Calculated Molecular Weight: 715 aa, 82 kDa
• Observed Molecular Weight: 70-82 kDa
• GenBank Accession Number: BC035293
• Gene Symbol: MX2
• Gene ID (NCBI): 4600
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P20592
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Myxovirus resistance 2 (MX2, also known as MxB) is a member of both the dynamin family and the family of large GTPases. MX2 is an interferon-stimulated gene that inhibits the nuclear import of HIV-1 and interacts with the viral capsid and cellular nuclear transport machinery. MX2 mediates the effects of IFN signaling in a cell type and context-dependent manner that can influence cells sensitivity to MAPK pathway targeted therapies. MX2 is also associated with the tumorigenesis process in melanoma(PMID: 33734579).