NBCn1 Polyclonal antibody, PBS Only

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  WB analysis using 29442-1-AP (same clone as 29442-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29442-1-AP (NBCn1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29442-1-PBS in a different storage buffer formulation.

NBCn1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 29442-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

29442-1-PBS targets NBCn1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: NBCn1 fusion protein Ag30545
• Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
• Calculated Molecular Weight: 136 kDa
• Observed Molecular Weight: 136 kDa
• GenBank Accession Number: NM_003615
• Gene Symbol: NBCn1/SLC4A7
• Gene ID (NCBI): 9497
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9Y6M7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SLC4A7 also known as NBCn1, NBC3, NBC2, is an electroneutral Na(+)/HCO(3)(-) cotransporter (PMID: 14736710). SLC4A7 mediates the coupled movement of sodium and bicarbonate ions across the plasma membrane. SLC4A7 plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). SLC4A7 is expressed in testis, spleen, and retina. SLC4A7 may be a major regulator of extracellular pH of retina where light stimulation produces an extracellular alkalization and may contribute as a solute transporter to the prevention of retinal detachment(PMID: 9610397).