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  • Western Blot (WB) analysis of various lysates using NLRP12 Polyclonal antibody (30998-1-AP)

    WB analysis using 30998-1-AP (same clone as 30998-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30998-1-AP (NLRP12 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of rat liver tissue using NLRP12 Polyclonal antibody (30998-1-AP)

    IP experiment of rat liver using 30998-1-AP (same clone as 30998-1-PBS)

    IP result of anti-NLRP12 (IP:30998-1-AP, 4ug; Detection:30998-1-AP 1:500) with rat liver tissue lysate 2695 ug. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of PC-3 cells using NLRP12 Polyclonal antibody (30998-1-AP)

    IP experiment of PC-3 using 30998-1-AP (same clone as 30998-1-PBS)

    IP result of anti-NLRP12 (IP:30998-1-AP, 4ug; Detection:30998-1-AP 1:500) with PC-3 cells lysate 1575 ug. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

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Product Information

30998-1-PBS targets NLRP12 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NLRP12 fusion protein Ag34281 Predict reactive species
Full Name NLR family, pyrin domain containing 12
Calculated Molecular Weight 1061 aa, 120 kDa
Observed Molecular Weight 95-110 kDa
GenBank Accession NumberBC028069
Gene Symbol NLRP12
Gene ID (NCBI) 91662
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity Purification
UNIPROT IDP59046
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

NACHT, LRR and PYD domains-containing protein 12 (NLRP12) is also named as Monarch-1, NALP12, PYPAF7 and RNO. NLRP12 is as an essential cytosolic sensor for heme plus PAMPs-mediated PANoptosis, inflammation, and pathology (PMID: 37267949). NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18 (PMID: 37267949). NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production (PMID: 36719379).