PDCD6IP Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 12422-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 21 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, Jurkat cells, mouse liver tissue

Positive IP detected in:
Jurkat cells

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
programmed cell death 6 interacting protein

Calculated molecular weight:
868aa,96 kDa

Observed molecular weight:
96 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDCD6IP

Synonyms
AIP1, ALG 2 interacting protein 1, Alix, DRIP4, HP95, KIAA1375, PDCD6 interacting protein, PDCD6IP
Background

ALG-2-interacting protein 1 (ALIX), also known as AIP1 or Hp95, is encoded by PDCD6IP gene and is involved in cell death through mechanisms involving its binding partner ALG-2 (apoptosis-linked gene-2). ALG-2 is a 22-kDa protein containing five serially repetitive EF-hand structures and is defined as a regulator of calcium-induced apoptosis following endoplasmic reticulum (ER) stress. ALIX interacts with ALG-2 through its C-terminal proline-rich region and participates in formation of multivesicular bodies. Recent finding suggest that ALIX is a critical component of caspase 9 activation and apoptosis triggered by calcium.


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