PDS5B Polyclonal antibody, PBS Only

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  WB analysis using 28318-1-AP (same clone as 28318-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28318-1-AP (PDS5B antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28318-1-PBS in a different storage buffer formulation.

• 

  WB analysis of PC-3 using 28318-1-AP (same clone as 28318-1-PBS)

  PC-3 cells were subjected to SDS PAGE followed by western blot with 28318-1-AP (PDS5B antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28318-1-PBS in a different storage buffer formulation.

PDS5B Polyclonal Antibody for WB, Indirect ELISA

Cat No. 28318-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3, APRIN, AS3, CG008

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Product Information

28318-1-PBS targets PDS5B in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PDS5B fusion protein Ag27977
• Full Name: PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
• Calculated Molecular Weight: 165 aa
• Observed Molecular Weight: 150 kDa
• GenBank Accession Number: NM_015032
• Gene Symbol: PDS5B
• Gene ID (NCBI): 23047
• RRID: AB_2881111
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NTI5
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PDS5B (PDS5 Cohesin Scc1-like Protein B) is a protein associated with sister chromatid cohesion and maintenance of chromosome structure. It plays a significant role in cell cycle regulation, DNA repair, and gene expression. PDS5B interacts with the cohesin complex to ensure the proper separation of sister chromatids during cell division. Additionally, PDS5B is crucial in DNA damage repair, particularly during homologous recombination, helping to maintain genomic stability. It also indirectly affects gene expression and chromatin structure by modulating the function of the cohesin complex. PDS5B is widely expressed during embryonic development and is highly expressed in the brain and testes in adulthood. Its dysfunction is associated with multiple diseases, including Cohesinopathies and Cornelia de Lange syndrome.