|Positive WB detected in||pig spinal cord tissue, human brain tissue, mouse testis tissue|
|Positive IHC detected in||human gliomas tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
12717-1-AP targets PMP2 in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat, pig samples.
|Tested Reactivity||human, mouse, rat, pig|
|Cited Reactivity||human, mouse, pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||PMP2 fusion protein Ag3411|
|Full Name||peripheral myelin protein 2|
|Calculated molecular weight||132 aa, 15 kDa|
|Observed molecular weight||15-20 kDa|
|GenBank accession number||BC034997|
|Gene ID (NCBI)||5375|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
PMP2 (peripheral myelin protein-2, also known as P2) is one of the major proteins of peripheral myelin and appears to be related to the transport of fatty acids or the metabolism of myelin lipids.P2 constitutes up to 15% of total protein of peripheral nervous system (PNS) myelin. It is also present in small amounts in central nervous system (CNS) myelin, being abundant in spinal cord and brain stem myelin. As a structural protein, P2 is thought to stabilize the myelin membranes.
Cell Mol Neurobiol
The Role of Peripheral Myelin Protein 2 in Remyelination.
Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.
Hum Mol Genet
Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.
A role of peripheral myelin protein 2 in lipid homeostasis of myelinating schwann cells.
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.
Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction.