|Positive WB detected in||pig spinal cord tissue, human brain tissue, mouse testis tissue|
|Positive IHC detected in||human gliomas tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
12717-1-AP targets PMP2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
|Tested Reactivity||human, mouse, rat, pig|
|Cited Reactivity||human, mouse, rat, pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||PMP2 fusion protein Ag3411|
|Full Name||peripheral myelin protein 2|
|Calculated molecular weight||132 aa, 15 kDa|
|Observed molecular weight||15-20 kDa|
|GenBank accession number||BC034997|
|Gene ID (NCBI)||5375|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
PMP2 (peripheral myelin protein-2, also known as P2) is one of the major proteins of peripheral myelin and appears to be related to the transport of fatty acids or the metabolism of myelin lipids.P2 constitutes up to 15% of total protein of peripheral nervous system (PNS) myelin. It is also present in small amounts in central nervous system (CNS) myelin, being abundant in spinal cord and brain stem myelin. As a structural protein, P2 is thought to stabilize the myelin membranes.
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Disentangling glial diversity in peripheral nerves at single-nuclei resolution.
Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction.
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.
Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice.
A role of peripheral myelin protein 2 in lipid homeostasis of myelinating schwann cells.