PMP2 Polyclonal antibody

PMP2 Polyclonal Antibody for IHC, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat, pig

Applications

WB, IHC, IF,ELISA

Conjugate

Unconjugated

Cat no : 12717-1-AP

Synonyms

FABP8, M FABP, MP2, Myelin P2 protein, P2, peripheral myelin protein 2, PMP2



Tested Applications

Positive WB detected inpig spinal cord tissue, human brain tissue, mouse testis tissue
Positive IHC detected inhuman gliomas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

12717-1-AP targets PMP2 in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Reactivity human, mouse, rat, pig
Cited Reactivity human, mouse, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PMP2 fusion protein Ag3411
Full Name peripheral myelin protein 2
Calculated molecular weight 132 aa, 15 kDa
Observed molecular weight 15-20 kDa
GenBank accession numberBC034997
Gene symbol PMP2
Gene ID (NCBI) 5375
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

PMP2 (peripheral myelin protein-2, also known as P2) is one of the major proteins of peripheral myelin and appears to be related to the transport of fatty acids or the metabolism of myelin lipids.P2 constitutes up to 15% of total protein of peripheral nervous system (PNS) myelin. It is also present in small amounts in central nervous system (CNS) myelin, being abundant in spinal cord and brain stem myelin. As a structural protein, P2 is thought to stabilize the myelin membranes.

Protocols

Product Specific Protocols
WB protocol for PMP2 antibody 12717-1-APDownload protocol
IHC protocol for PMP2 antibody 12717-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Exp Clin Cancer Res

ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Authors - Mengzhao Zhang
mouseIF

Cell Mol Neurobiol

The Role of Peripheral Myelin Protein 2 in Remyelination.

Authors - Mark Stettner
humanWB, IF

BMC Cancer

Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.

Authors - Monticone Massimiliano M
MOUSE

Hum Mol Genet

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Authors - Sophie Belin
mouseIHC

Glia

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating schwann cells.

Authors - Jennifer Zenker
mouseWB

Elife

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.

Authors - Sophie B Siems