- Featured Product
- KD/KO Validated
PGC1a Polyclonal antibody
PGC1a Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (4)
Applications
WB, IF, IHC, chIP, ELISA
Conjugate
Unconjugated
Cat no : 20658-1-AP
Synonyms
Validation Data Gallery
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 2 publications below |
| WB | See 43 publications below |
| IHC | See 8 publications below |
| IF | See 5 publications below |
| ChIP | See 1 publications below |
Product Information
20658-1-AP targets PGC1a in WB, IF, IHC, chIP, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse, rat, goat, chicken, zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| Calculated Molecular Weight | 91 kDa |
| Observed Molecular Weight | 91-98 kDa |
| GenBank Accession Number | NM_013261 |
| Gene Symbol | PPARGC1A |
| Gene ID (NCBI) | 10891 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PPARGC1A exists various isoforms and range of molecular weight of isoforms are 30-50 kDa and 90-110 kDa.
Publications
| Species | Application | Title |
|---|---|---|
Redox Biol Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. | ||
Autophagy FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. | ||
Part Fibre Toxicol Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. | ||
Oxid Med Cell Longev Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy. | ||
Redox Biol Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro. |
