PSMD4 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 14899-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HeLa cells, Jurkat cells, NIH/3T3 cells, Raji cells, rat spleen tissue, RAW 264.7 cells

Positive IHC detected in:
human lung cancer tissue, human lung cancer tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Calculated molecular weight:
41 kDa

Observed molecular weight:
50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PSMD4

Synonyms
AF, AF 1, Antisecretory factor 1, ASF, MCB1, PSMD4, pUB R5, Rpn10, S5A
Background

PSMD4, also named as MCB1, AF or ASF, belongs to the proteasome subunit S5A family. PSMD4 is a 50-kD subunit of the regulatory complex of the 26S proteasome. It binds and presumably selects ubiquitin-conjugates for destruction. PSMD4 displays selectivity for longer polyubiquitin chains. It modulates intestinal fluid secretion. PSMD4 is exposed on the sperm acrosomal surface, a notion that was further supported by the binding of non-cell permeant, biotinylated proteasomal inhibitor ZL3VS to the sperm acrosome. It is involved in the sperm-ZP penetration during fertilization. (PMID: 20526895) This antibody is specific to PSMD4.


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