PTGER3 Polyclonal antibody, PBS Only

• 

  IHC staining of human brain using 14357-1-AP (same clone as 14357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 14357-1-AP (PTGER3 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14357-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human brain using 14357-1-AP (same clone as 14357-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 14357-1-AP (PTGER3 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14357-1-PBS in a different storage buffer formulation.

PTGER3 Polyclonal Antibody for IHC, Indirect ELISA

Cat No. 14357-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, Indirect ELISA

Synonyms

EP3, EP3 I, EP3 II, EP3 III, EP3 IV

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Product Information

14357-1-PBS targets PTGER3 in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag5711

  Product name: Recombinant human PTGER3 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-374 aa of BC024229

  Sequence: MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEEFWGN

• Full Name: prostaglandin E receptor 3 (subtype EP3)
• Calculated Molecular Weight: 43 kDa
• GenBank Accession Number: BC024229
• Gene Symbol: PTGER3
• Gene ID (NCBI): 5733
• RRID: AB_2237964
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P43115
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PTGER3 (Prostaglandin E Receptor 3), also known as EP3, is a G protein-coupled receptor (GPCR). Activates pathways involved in proliferation, migration, and apoptosis, often via cross-talk with PI3K-AKT and MAPK cascades (PMID: 38566528). High PTGER3 levels drive tumorigenesis, angiogenesis, and cisplatin resistance via the Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis (PMID: 30655206).