Product Information
87129-2-PBS targets Phospho-TAK1 (Ser439) in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | mitogen-activated protein kinase kinase kinase 7 |
| Calculated Molecular Weight | 67 kDa |
| Observed Molecular Weight | 75-85 kDa |
| GenBank Accession Number | NM_145331 |
| Gene Symbol | TAK1 |
| Gene ID (NCBI) | 6885 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O43318 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
MAP3K7(Mitogen-activated protein kinase kinase kinase 7) is also named TAK1 and belongs to the MAP kinase kinase kinase subfamily. Phospho-TAK1 (Ser439) refers to the phosphorylated form of TAK1 at serine residue 439. TAK1, also known as Transforming Growth Factor-beta activated kinase 1, is a key kinase involved in the regulation of various signaling pathways, including those related to inflammation, immune responses, and cell survival. The phosphorylation of TAK1 at Ser439 is an important post-translational modification that can affect its activity and interaction with other proteins within these pathways. This phosphorylation event is crucial for TAK1's role in signal transduction and its involvement in cellular processes such as the activation of NF-κB and MAPK pathways. It plays a significant role in the activation of downstream signaling cascades that regulate various cellular processes, including cell growth, proliferation, and survival. This antibody is equivalent to Ser412 in mice.
