S1PR1/EDG1 Polyclonal antibody, PBS Only

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  WB analysis using 29318-1-AP (same clone as 29318-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29318-1-AP (S1PR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29318-1-PBS in a different storage buffer formulation.

S1PR1/EDG1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 29318-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

S1PR1, EDG1, EDG 1, ECGF1, D1S3362

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Product Information

29318-1-PBS targets S1PR1/EDG1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: S1PR1/EDG1 fusion protein Ag28083
• Full Name: sphingosine-1-phosphate receptor 1
• Calculated Molecular Weight: 43 kDa
• Observed Molecular Weight: 45-50 kDa
• GenBank Accession Number: BC018650
• Gene Symbol: S1PR1
• Gene ID (NCBI): 1901
• RRID: AB_2918281
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P21453
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

S1PR1 (sphingosine-1-phosphate receptor 1), also known as S1P1 or EDG1, is one of five G-protein-coupled receptors for sphingosine-1-phosphate (S1P) (PMID: 18787560). S1P1 and its receptors have important regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems (PMID: 21339489). S1PR1 is widely expressed in various cell types, including endothelial cells and lymphocytes (PMID: 14737169). S1P-S1PR1 plays a major role in lymphocyte egress and chemotaxis, cell proliferation and survival, and tumor angiogenesis and metastasis (PMID: 21102457).