SIRT2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15345-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 49 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, mouse brain tissue, rat kidney tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human heart tissue, human breast cancer tissue, human heart tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

Calculated molecular weight:
43 kDa

Observed molecular weight:
37-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SIRT2

Synonyms
SIR2, SIR2 like protein 2, SIR2L, SIR2L2, SIRT2
Background

The silent information regulator(SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. SIR2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis. SIR2 is widely expressed, highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. This antibody is a rabbit polyclonal antibody raised against the N-terminal 352 residues of human SIR2 protein.


Back
to top