|Positive WB detected in||A375 cells, K-562 cells|
|Western Blot (WB)||WB : 1:500-1:2400|
|Sample-dependent, check data in validation data gallery|
13526-1-AP targets ZnT6 in WB,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||chicken, human, mouse, Yellow catfish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ZnT6 fusion protein Ag4403|
|Full Name||solute carrier family 30 (zinc transporter), member 6|
|Calculated molecular weight||460 aa, 50 kDa|
|Observed molecular weight||51 kDa|
|GenBank accession number||BC032525|
|Gene ID (NCBI)||55676|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ZnT6 (encoded by SLC30A6) is a member of zinc transporters. ZnT6 is localized on the membrane of the Golgi apparatus as well as cytoplasmic vesicles. It may function in transporting the cytoplasmic zinc into the Golgi apparatus as well as the vesicular compartment. Altered expression of ZnT6 may correlate to neural diseases including Alzheimer's disease. Several isoforms of ZnT6 exist due to the alternative splicing, with MW around 48-56 kDa.
Acta Neuropathol Commun
Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.
Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.
J Neurosci Res
Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.
Biochim Biophys Acta Gene Regul Mech
Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.
J Biol Chem
Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.