SUCNR1 Polyclonal antibody

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  IHC staining of mouse kidney using 31987-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 31987-1-AP (SUCNR1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of mouse liver using 31987-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 31987-1-AP (SUCNR1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

SUCNR1 Polyclonal Antibody for IHC, ELISA

Cat No. 31987-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, ELISA

Synonyms

Succinate receptor 1, P2Y purinoceptor 1-like, P2Y purinoceptor 1 like, G-protein coupled receptor 91, GPR91

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Tested Applications

• Positive IHC detected in: mouse kidney tissue, mouse liver tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

31987-1-AP targets SUCNR1 in IHC, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SUCNR1 fusion protein Ag34053
• Full Name: succinate receptor 1
• GenBank Accession Number: BC030948
• Gene Symbol: SUCNR1
• Gene ID (NCBI): 56670
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9BXA5
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SUCNR1 (Succinate Receptor 1), also known as GPR91, belongs to the family of G protein-coupled receptors (GPCRs) (PMID: 26808164). SUCNR1 has been identified as a receptor for the metabolite succinate, which functions as a metabolic stress signal in various tissues including the liver, kidney, adipose tissue, and retina (PMID: 29968758). SUCNR1 is crucial in linking metabolic stress, inflammation, and energy homeostasis. It mediates signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and regulated processes.