TAZ Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66500-1-Ig |CloneNo.: 2A12A10

Featured Product KD/KO validated

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
Human, rat, mouse

Positive WB detected in:
MCF-7 cells, HepG2 cells, HSCT6 cells, NIH/3T3 cells

Positive IHC detected in:
human liver cancer tissue, human breast cancer tissue

Recommended dilution:
WB : 1:2000-1:12000
IHC : 1:300-1:1200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
WW domain containing transcription regulator 1

Calculated molecular weight:
44 kDa

Observed molecular weight:
55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
WWTR1

Synonyms
DKFZp586I1419, TAZ, WWTR1
Background

TAZ, also referred as WWTR1, is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 protein. TAZ is expressed in many primary tumors, such as breast cancer, thyroid carcinoma, colorectal cancer, and glioma. TAZ has been reported to be one of the nuclear effectors of Hippo-related pathways that regulate organ size control, cancer stem cell (CSC) properties, and epithelial–mesenchymal transition (EMT). TAZ has been defined for its role in the nucleus, where it functions directly as a transcriptional regulator by interacting with several nuclear factors as Runx2/Cbfa1, NHERF-2, TEF-1, TBX5, PAX3, PAX8 and TTF-1.


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