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TNFAIP8 Monoclonal antibody, PBS Only

TNFAIP8 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3D2F7

Cat no : 67737-1-PBS

Synonyms

GG2 1, MDC 3.13, NDED, SCC S2, SCCS2, TNF alpha induced protein 8, TNF induced protein GG2 1, TNFAIP8

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TNFAIP8 Monoclonal antibody (67737-1-Ig)

    WB analysis using 67737-1-Ig (same clone as 67737-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67737-1-Ig (TNFAIP8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67737-1-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67737-1-PBS targets TNFAIP8 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen TNFAIP8 fusion protein Ag8805
Full Name tumor necrosis factor, alpha-induced protein 8
Calculated Molecular Weight 198 aa, 23 kDa
Observed Molecular Weight19-21 kDa
GenBank Accession NumberBC007014
Gene Symbol TNFAIP8
Gene ID (NCBI) 25816
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TNFAIP8 (tumor necrosis factor, alpha-induced protein 8), also called SCC-S2/GG2-1/NDED, is associated with enhanced cell survival and inhibition of apoptosis. The induction of TNFAIP8 by TNF depends on the activation of NFκB. TNFAIP8 suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. TNFAIP8 is expressed in adult spleen, lymph node, thymus, thyroid, bone marrow, and placenta, and in fetal liver, lung, and kidney at high levels, also expressed in various tumor tissues and all cancer cell lines tested.