UTP11L Polyclonal antibody

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  WB analysis using 31935-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 31935-1-AP (UTP11L antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 31935-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 31935-1-AP (UTP11L antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

UTP11L Polyclonal Antibody for WB, ELISA

Cat No. 31935-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Probable U3 small nucleolar RNA-associated protein 11, U3 snoRNA-associated protein 11, UTP11 , UTP11 Small Subunit Processome Component, UTP11-like protein

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Tested Applications

• Positive WB detected in: HEK-293 cells, K-562 cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:16000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

31935-1-AP targets UTP11L in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag36182

  Product name: Recombinant human UTP11L protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-253 aa of BC005182

  Sequence: MAAAFRKAAKSRQREHRERSQPGFRKHLGLLEKKKDYKLRADDYRKKQEYLKALRKKALEKNPDEFYYKMTRVKLQDGVHIIKETKEEVTPEQLKLMRTQDVKYIEMKRVAEAKKIERLKSELHLLDFQGKQQNKHVFFFDTKKEVEQFDVATHLQTAPELVDRVFNRPRIETLQKEKVKGVTNQTGLKRIAKERQKQYNCLTQRIEREKKLFVIAQKIQTRKDLMDKTQKVKVKKETVNSPAIYKFQSRRKR

• Full Name: UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
• Observed Molecular Weight: 30 kDa
• GenBank Accession Number: BC005182
• Gene Symbol: UTP11L
• Gene ID (NCBI): 51118
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9Y3A2
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

UTP11L is a nucleolar protein and a key component of the U3 small nucleolar ribonucleoprotein (U3 snoRNP). It primarily participates in the processing of ribosomal RNA (rRNA) precursors, playing a critical role in the maturation of 18S rRNA and the assembly of the 40S small ribosomal subunit. As a core regulator of ribosome biogenesis, UTP11L maintains the stability of the rRNA processing complex by interacting with other members of the UTP protein complex. Studies have shown that dysregulation of UTP11L expression is closely associated with abnormal cell proliferation. Its upregulation has been observed in various tumors, such as hepatocellular carcinoma, and may promote tumor progression by affecting ribosome production. Currently, UTP11L is considered a potential tumor biomarker, and the specific molecular mechanisms by which it functions in ribosome biogenesis remain an important focus in cell biology research.