ZCCHC12 Polyclonal antibody

ZCCHC12 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 26442-1-AP

Synonyms

SIZN, SIZN1, ZCCHC12

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Validation Data Gallery

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  WB analysis using 26442-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 26442-1-AP (ZCCHC12 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue, rat brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

26442-1-AP targets ZCCHC12 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ZCCHC12 fusion protein Ag23858
• Full Name: zinc finger, CCHC domain containing 12
• Observed Molecular Weight: 35-40 kDa
• GenBank Accession Number: BC031241
• Gene Symbol: ZCCHC12
• Gene ID (NCBI): 170261
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Zinc finger CCHC domain-containing protein 12 (ZCCHC12) functions as a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway (PMID: 19578717; 19416967). It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex (PMID: 18160706). It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. A variant in ZCCHC12 may play a role in X-linked cognitive disability (PMID: 18798319).