androgen receptor Monoclonal antibody, PBS Only

androgen receptor Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 66747-1-PBS
Clone No.1F7C12

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, IF-P, ChIP, Indirect ELISA

androgen receptor,AR, AR, 1F7C12, DHTR, NR3C4

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Published Applications

ChIPSee 1 publications below

Product Information

66747-1-PBS targets androgen receptor in WB, IHC, IF/ICC, IF-P, ChIP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen

CatNo: Ag17291

Product name: Recombinant human AR protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-285 aa of BC132975

Sequence: MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPL

Predict reactive species
Full Name androgen receptor
Calculated Molecular Weight 914 aa, 99 kDa
Observed Molecular Weight 110-120 kDa
GenBank Accession NumberBC132975
Gene Symbol AR
Gene ID (NCBI) 367
RRIDAB_2882094
Conjugate Unconjugated
FormLiquid
Purification MethodProtein A purification
UNIPROT IDP10275
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

AR, also named as DHTR and NR3C4, belongs to the nuclear hormone receptor family and NR3 subfamily. AR is a ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. AR is activated, but not phosphorylated, by HIPK3. Defects in AR are the cause of androgen insensitivity syndrome (AIS), previously known as testicular feminization syndrome (TFM), which is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) which also known as Kennedy disease. Defects in AR may play a role in metastatic prostate cancer. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) which also known as Reifenstein syndrome. AR exists various isoforms with MW 110-120 kDa and 75-80 kDa. (PMID: 19244107 )

Publications

SpeciesApplicationTitle
humanChIP

Sci Rep

Characterization of RNA editing gene APOBEC3C as a candidate tumor suppressor in prostate cancer

Authors - Li-Yang Wang
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