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Humankine® Human Cell-expressed Cytokines and Growth Factors

Cytokines are small secreted proteins. Cytokines are a category of signaling molecules that mediate and regulate immunity, inflammation, and hematopoiesis. They exist in broad families that are structurally related but exhibit diverse functions (e.g., in the TNF/TNF receptor superfamily, lymphokines are also known as interleukins (ILs)).

Growth factors promote cellular differentiation and proliferation. They act on target tissues and regulate processes including tissue morphogenesis, angiogenesis, cell differentiation, and neurite outgrowth. They are essential growth-regulatory molecules for cell culture maintenance. Non-transformed cells show an absolute requirement for growth factors for maintenance in cell culture and for most cell types, more than one type of growth factor is required. Under cell culture conditions, growth factors are the most rapidly depleted media components and thus become a rate-limiting factor for further proliferation. Commonly used growth factors in tissue engineering include fibroblast growth factors (FGFs), vascular epithelial growth factors (VEGFs), and transforming growth factors-β (TGF-βs). The loss or decreased level of growth factors is common in neoplastically transformed cells and may lead to an uncontrolled growth of cancer cells.

See below for a full list of Humankine® cytokines and growth factors.

Catalog number Product Name EC50 Purity Citations
HZ-1138 Activin A ≤5 ng/mL >95% 14
HZ-1222 beta NGF ≤4 ng/mL >95%  
HZ-1128 BMP-2 ≤60 ng/mL >95% 18
HZ-1045 BMP-4 ≤20 ng/mL >95% 33
HZ-1229 BMP-7 ≤100 ng/mL >95% 6
HZ-1168 EPO ≤2.5 ng/mL >95% 2
HZ-1285 FGF Basic TS ≤0.5 ng.mL >95% 3
HZ-1218 FGF-4 ≤1.25 ng/mL >95%  
HZ-1100 FGF-7 (KGF) ≤7.5 ng/mL >95% 1
HZ-1103 FGF-8b ≤60 ng/mL >95% 1
HZ-1151 FLT3 Ligand ≤0.8 ng/mL >95% 9
HZ-1207 G-CSF ≤0.1 ng/mL >95% 3
HZ-1311 GDNF ≤ 10 ng/mL  >95%  
HZ-1002 GM-CSF ≤2 ng/mL >95% 7
HZ-1084 HGF ≤20 ng/mL >95% 8
HZ-1007 HGH  ≤2 ng/mL >95% 1
HZ-1066 IFN alpha 2A ≤0.4 ng/mL >95% 3
HZ-1072 IFN alpha 2B ≤0.12 ng/mL >95%  
HZ-1298 IFN beta ≤0.1 ng/mL >95%  
HZ-1301 IFN gamma ≤0.05 ng/mL >95% 1
HZ-1164 IL-1 beta ≤0.1 ng/mL >95% 15
HZ-1015 IL-2 ≤5 ng/mL >95%  
HZ-1004 IL-4 ≤0.6 ng/mL >95% 10
HZ-1019 IL-6 ≤1 ng/mL >95% 17
HZ-1281 IL-7 ≤1 ng/mL >95%  
HZ-1240 IL-9 ≤1 ng/mL >95%  
HZ-1145 IL-10 ≤1.5 ng/mL >95% 4
HZ-1256 IL-12 ≤2 ng/mL >95% 3
HZ-1113 IL-17 (IL-17A) ≤10 ng/mL >95% 3
HZ-1116 IL-17F ≤10 ng/mL >95%  
HZ-1254 IL-23 ≤30 ng/mL >95% 10
HZ-1275 IL-27 ≤12 ng/mL >95% 1
HZ-1235 IL-28A ≤5 ng/mL >95%  
HZ-1245 IL-28B ≤1 ng/mL >95%  
HZ-1156 IL-29 ≤5 ng/mL >95%  
HZ-1292 LIF ≤0.2 ng/mL >95%  
HZ-1192 M-CSF ≤4 ng/mL >95% 4
HZ-1118 Noggin ≤25 ng/mL >95% 4
HZ-1030 Oncostatin M ≤10 ng/mL n/a 2
HZ-1215 PDGF-aa ≤25 ng/mL >95%  
HZ-1308 PDGFbb  ≤3 ng/mL >95%  
HZ-1278 Pleiotrophin-PTN   >95%  
HZ-1161 pro-IGF-II ≤50 ng/mL >95% 1
HZ-1024 SCF ≤25 ng/mL >95% 8
HZ-1011 TGF beta 1 ≤0.5 ng/mL >95% 66
HZ-1092 TGF beta 2 ≤0.5 ng/mL >95%  4
HZ-1090 TGF beta 3 ≤0.5 ng/mL >95% 8
HZ-1014 TNF alpha ≤1 ng/mL >95%  8
HZ-1204 VEGF 121 ≤15 ng/mL >95%  10
HZ-1038 VEGF 165 ≤15 ng/mL >95%  10

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