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HumanKine® Human Cell-expressed Cytokines and Growth Factors

Cytokines are small secreted proteins. Cytokines are a category of signaling molecules that mediate and regulate immunity, inflammation, and hematopoiesis. They exist in broad families that are structurally related but exhibit diverse functions (e.g., in the TNF/TNF receptor superfamily, lymphokines are also known as interleukins (ILs)).

Growth factors promote cellular differentiation and proliferation. They act on target tissues and regulate processes including tissue morphogenesis, angiogenesis, cell differentiation, and neurite outgrowth. They are essential growth-regulatory molecules for cell culture maintenance. Non-transformed cells show an absolute requirement for growth factors for maintenance in cell culture and for most cell types, more than one type of growth factor is required. Under cell culture conditions, growth factors are the most rapidly depleted media components and thus become a rate-limiting factor for further proliferation. Commonly used growth factors in tissue engineering include fibroblast growth factors (FGFs), vascular epithelial growth factors (VEGFs), and transforming growth factors-β (TGF-βs). The loss or decreased level of growth factors is common in neoplastically transformed cells and may lead to an uncontrolled growth of cancer cells.

See below for a full list of HumanKine® cytokines and growth factors.

Product Name Catalog number Activity spec. Purity Citations
Activin A HZ-1138 ≤5 ng/mL EC50 >95% 16
beta NGF HZ-1222 ≤3 ng/mL EC50 >95%  
BMP-2 HZ-1128 ≤60 ng/mL EC50 >95% 21
BMP-4 HZ-1045 ≤10 ng/mL EC50 >95% 41
BMP-7 HZ-1229 ≤100 ng/mL EC50 >95% 6
EPO HZ-1168 ≤2.5 ng/mL EC50 >95% 3
FGF Basic TS HZ-1285 ≤0.5 ng.mL EC50 >95% 8
FGF-4 HZ-1218 ≤1.25 ng/mL EC50 >95%  
FGF-7 (KGF) HZ-1100 ≤7.5 ng/mL EC50 >95% 1
FGF-8b HZ-1103 ≤10 ng/mL EC50 >95% 1
FLT3 Ligand HZ-1151 ≤0.8 ng/mL EC50 >95% 10
G-CSF HZ-1207 ≤0.1 ng/mL EC50 >95% 6
GDNF HZ-1311 ≤ 10 ng/mL  EC50 >95%  
GM-CSF HZ-1002 ≤0.5 ng/mL EC50 >95% 10
HGF HZ-1084 ≤20 ng/mL EC50 >95% 8
HGH HZ-1007 ≤0.5 ng/mL EC50 >95% 2
IFN alpha 2A HZ-1066 ≤0.4 ng/mL EC50 >95% 4
IFN alpha 2B HZ-1072 ≤0.12 ng/mL EC50 >95% 2
IFN beta HZ-1298 ≤0.1 ng/mL EC50 >95%  
IFN gamma HZ-1301 ≤0.05 ng/mL EC50 >95% 3
IL-1 beta HZ-1164 ≤0.05 ng/mL EC50 >95% 16
IL-2 HZ-1015 ≤5 ng/mL EC50 >95% 5
IL-4 HZ-1004 ≤0.6 ng/mL EC50 >95% 17
IL-6 HZ-1019 ≤0.5 ng/mL EC50 >95% 19
IL-7 HZ-1281 ≤1 ng/mL EC50 >95%  
IL-9 HZ-1240 ≤1 ng/mL EC50 >95% 2
IL-10 HZ-1145 ≤1.5 ng/mL EC50 >95%  
IL-12 HZ-1256 ≤2 ng/mL EC50 >95% 3
IL-17 (IL-17A) HZ-1113 ≤2 ng/mL EC50 >95% 3
IL-17F HZ-1116 ≤10 ng/mL EC50 >95%  
IL-23 HZ-1254 ≤4 ng/mL EC50 >95% 11
IL-27 HZ-1275 ≤12 ng/mL EC50 >95% 1
IL-28A HZ-1235 ≤5 ng/mL EC50 >95% 2
IL-28B HZ-1245 ≤1 ng/mL EC50 >95%
IL-29 HZ-1156 ≤5 ng/mL EC50 >95% 2
Lefty-1 HZ-1109 ≤40 ng/mL EC50 >95% 1
LIF HZ-1292 ≤0.2 ng/mL EC50 >95%  
M-CSF HZ-1192 ≤4 ng/mL EC50 >95% 5
Noggin HZ-1118 ≤15 ng/mL EC50 >95% 5
Oncostatin M HZ-1030 ≤1 ng/mL EC50 >95%
3
PDGF-aa HZ-1215 ≤10 ng/mL EC50 >95%  
PDGFbb HZ-1308  ≤3 ng/mL EC50 >95% 1
Pleiotrophin-PTN HZ-1278 N/A >95%  
pro-IGF-II HZ-1161 ≤50 ng/mL EC50 >95% 1
SCF HZ-1024 ≤25 ng/mL EC50 >95% 9
TGF beta 1 HZ-1011 ≤0.5 ng/mL EC50 >95% 82
TGF beta 2 HZ-1092 ≤0.5 ng/mL EC50 >95%  4
TGF beta 3 HZ-1090 ≤0.5 ng/mL EC50 >95% 8
TNF alpha HZ-1014 ≤0.5 ng/mL EC50 >95%  9
VEGF 121 HZ-1204 ≤15 ng/mL EC50 >95%  14
VEGF 165 HZ-1038 ≤5 ng/mL EC50 >95%  11

 

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