Product Information
10033-1-Ig targets dynactin-2 in ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Predict reactive species |
| Full Name | dynactin 2 (p50) |
| Calculated Molecular Weight | 50 kDa |
| GenBank Accession Number | BC000718 |
| Gene Symbol | Dynamitin |
| Gene ID (NCBI) | 10540 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q13561 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believing to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, and thus extend to vesicle trafficking and membrane integrity. Dynamitin was so named because of its overexpression causes dynactin complex, which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is the MacMARCKS binding protein and residues 59-83 is responsible for calmodulin binding. This antibody is is against the N terminal 83AA of full length p50 dynamitin.
