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Interactions in Neurodegenerative Disorders
Why is Alpha-Synuclein important? Disease spectrum and Alpha-Synuclein Product Focus: Alpha-Synuclein Latest Scientific Facts about Alpha-Synuclein |
Alpha-Synuclein is a 14-19 kDa phosphoprotein primarily localized in the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity.
Alpha-Synuclein was the first missense mutation identified as a cause of familial Parkinson’s disease.
Aggregated and hyper-phosphorylated forms of Alpha-Synuclein are the major components of Lewy bodies.
Alpha-Synuclein is involved in regulation of the dopaminergic pathway.
Alpha-Synuclein reduces neuronal responsiveness to various apoptotic stimuli, leading to decreased caspase-3 activation.
Alpha-Synuclein intermediate oligomers/protofibrils are thought to be the major neurotoxic species.
Alpha-Synuclein is a target for the treatment of Parkinson’s disease; a humanized monoclonal anti-Alpha-Synuclein (PRX002) is currently under Phase 1 trails.
Alpha-Synucleinopathies (protein aggregates in neurons, nerve fibers, and glial cells)
Dementia (Lewy body)
Multiple system atrophy (Alpha-Synuclein protein prions)
Product Focus: Alpha-Synuclein | ||
Catalog number | Type | Applications |
10842-1-AP | Rabbit polyclonal | ELISA, WB, IHC, IF |
View the Alpha-Synuclein product page here |
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Immunofluorescence analysis of SH-SY5Y cells (human neuroblastoma) labeling Alpha-Synuclein with 10842-1-AP Proteintech antibody at a dilution of 1:25. Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L) was used as the secondary antibody and DAPI was used as the nuclear counterstain. |
Alpha-synuclein contributes to malignant progression of human meningioma via the Akt/mTOR pathway.
Alpha-Synuclein overexpression-induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.
Mutant Alpha-Synuclein causes age-dependent neuropathology in monkey brain.
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Catalog number |
Gene ID |
Antigen Name |
Application |
22524-1-AP | 6531 | DAT | ELISA, IHC, WB, IP |
18355-1-AP | 5337 | PLD1 | ELISA, WB, IF, IP |
14060-1-AP | 5071 | PARK2 | ELISA, WB, IF |