Brown Adipose Tissue Product Feature

New discoveries with Proteintech antibodies on the fat you don’t want to lose

Two nature papers reveal further details on the roles of brown and beige adipose tissue.

Brown adipose tissue is a form of fat that helps increase body temperature through “non-shivering thermogenesis”. Brown adipose fat activation is of much interest to researchers due to its high metabolic capacity which could be utilized therapeutically in obesity-related diseases. Prolonged cold exposure also causes white adipocytes to brown or beige and adopt more metabolically active brown-like phenotypes.

A recent publication in Nature by Seiki et al. discovered that brown fat activation through cold inhibits tumor growth by interfering with the glycolysis-based metabolism in cancer cells. This study provides a novel paradigm as an adjunct to other cancer therapies. In a different Nature paper, Wang et al. discovered how beige adipose is activated via PRDM16, and how increasing its post-translational stability can counteract diet-induced obesity in mice. Together, these papers cited 9 Proteintech antibodies in their research.


Immunohistochemical analysis of paraffin-embedded mouse brown adipose tissue slide using 23673-1-AP UCP1 antibody

IHC analysis of mouse brown adipose tissue slide using 23673-1-AP (UCP1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).


Popular antibodies for brown adipose research: