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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human FGF-7 (KGF)

Activity

Typically ≤ 7.5 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1100

Synonyms

FGF 7, FGF7, FGF-7, Fibroblast growth factor 7, HBGF 7, Keratinocyte growth factor, KGF



Technical Specifications

GeneID 2252
Species human
Expression HEK293
Activity Typically ≤ 7.5 ng/mL EC50
Purity >95%
Molecular Mass 17 and 30 kDa, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity Human, monkey

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human FGF-7 (KGF) is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 17 and 30 kDa. FGF-7 appears to act on epithelial cells. It also seems to motivate and stimulate proliferation, migration, and differentiation of these cells. It plays a significant role in development, morphogenesis, wound healing, angiogenesis, and tumorigenesis. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Authentic glycosylation contributes to stability in cell growth media and other applications.

Background

Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), belongs to the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (PMID 11276432, 15863033). FGF-7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes (PMID 15327889).

Synonyms

FGF 7, FGF7, FGF-7, Fibroblast growth factor 7, HBGF 7, Keratinocyte growth factor, KGF

Publications

SpeciesTitle
human

J Invest Dermatol

Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis.

Authors - JohannaCanady