- HEK293 expressed
- Endotoxin-free
- Animal-component free
Animal-free Recombinant Human FGF-7 (KGF)
Cat no : HZ-1100
Synonyms
FGF 7, FGF7, FGF-7, Fibroblast growth factor 7, HBGF 7, Keratinocyte growth factor, KGF
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Technical Specifications
| GeneID | 2252 |
| Species | human |
| Expression | HEK293 |
| Activity | Typically ≤ 7.5 ng/mL EC50 |
| Purity | >95% |
| Molecular Mass | 17 and 30 kDa, monomer, glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | Human, monkey |
Stability and Reconstitution
| Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Product Description
Animal-free Recombinant Human FGF-7 (KGF) is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 17 and 30 kDa. FGF-7 appears to act on epithelial cells. It also seems to motivate and stimulate proliferation, migration, and differentiation of these cells. It plays a significant role in development, morphogenesis, wound healing, angiogenesis, and tumorigenesis. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Authentic glycosylation contributes to stability in cell growth media and other applications.
Background
Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), belongs to the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (PMID 11276432, 15863033). FGF-7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes (PMID 15327889).
Synonyms
FGF 7, FGF7, FGF-7, Fibroblast growth factor 7, HBGF 7, Keratinocyte growth factor, KGF
Publications
| Species | Title |
|---|---|
J Invest Dermatol Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis. |
