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Animal-free Recombinant Human FGF-7 (KGF)1 Publications

Catalog number: HZ-1100

HEK293 expressed Endotoxin-free Animal-component free

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Format: Lyophilized

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Technical Specifications

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FGF-7 (KGF) activity assay

The activity was determined by the dose-dependent stimulation of the proliferation of 4MBr-5 cells (monkey epithelial cell line) using Promega CellTiter96® Aqueous Non-Radioactive Cell Proliferation Assay.

FGF-7 (KGF) purity

The protein was resolved by SDS-polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. R represents reducing conditions and NR represents non-reducing conditions.

GeneID:
2252
Species:
Human
Expression:
HEK293
Activity:
Typically ≤ 7.5 ng/mL EC50
Purity:
>95%
Molecular Mass:
17 and 30 kDa, monomer, glycosylated
Formulation
1x PBS, See Certificate of Analysis for details
Species Reactivity:
Human, monkey

Stability and Reconstitution

Stability and Storage:
Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.


Reconstitution:
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Product Description:

Animal-free Recombinant Human FGF-7 (KGF) is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 17 and 30 kDa. FGF-7 appears to act on epithelial cells. It also seems to motivate and stimulate proliferation, migration, and differentiation of these cells. It plays a significant role in development, morphogenesis, wound healing, angiogenesis, and tumorigenesis. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Authentic glycosylation contributes to stability in cell growth media and other applications.



Background:

Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), belongs to the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (PMID 11276432, 15863033). FGF-7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes (PMID 15327889).



Synonyms:
Keratinocyte Growth Factor, Fibroblast Growth Factor-7, HBGF-7, FGF7, FGF 7, KGF, Fibroblast Growth Factor 7, Fibroblast Growth Factor7, HBGF-7, FGF-7 (KGF)



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