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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human TGF beta 3

Activity

Typically ≤ 0.5 ng/mL EC50

Species Reactivity

Human

Purity

>95%

Publications

8

Cat no : HZ-1090

Synonyms

Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin TGFbeta3, Transforming Growth Factorβ2, Transforming Growth Factor β2, BSC1, BSC 1



Technical Specifications

GeneID 7043
Species Human
Expression HEK293
Activity Typically ≤ 0.5 ng/mL EC50
Purity >95%
Molecular Mass 25 kDa, homodimer, non-glycosylated
Formulation 50 mM NaOAc pH 3.7, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human TGF beta 3 is expressed from human 293 cells as a mature disulfide-linked homodimer with apparent molecular mass of 25 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. The cytokine is greater than 95% pure.

Background

The transforming growth factor beta-3 (TGFβ-3) protein is found throughout the body and is required for development before birth and throughout life. TGFβ-3 binds to the receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell. As part of the TGF-β a signalling pathway, the TGFβ-3 protein helps to control the growth and cell proliferation. The TGFβ-3 protein is especially abundant in skeletal muscles and plays a key role in their development. The protein is also involved in blood vessels formation, regulation of bone growth, and wound healing (PMID: 25835445; 23824657)

Synonyms

Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin TGFbeta3, Transforming Growth Factorβ2, Transforming Growth Factor β2, BSC1, BSC 1

Publications

SpeciesTitle
human

NPJ Microgravity

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.

Authors - William MWeiss
mouse

Mech Dev

Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice.

Authors - RainerSchmid
human

BMC Musculoskelet Disord

Matrix forming characteristics of inner and outer human meniscus cells on 3D collagen scaffolds under normal and low oxygen tensions.

Authors - RogerCroutze
human

BMC Musculoskelet Disord

Effect of interleukin-1β treatment on co-cultures of human meniscus cells and bone marrow mesenchymal stromal cells.

Authors - AnikaChowdhury
mouse

PLoS One

YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

Authors - RainerSchmid
human

PLoS One

Oxygen tension is a determinant of the matrix-forming phenotype of cultured human meniscal fibrochondrocytes.

Authors - Adetola BAdesida