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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Thrombin (Coagulation Factor II) protein

Activity

N/A

Species Reactivity

human

Purity

>95%

Cat no : HZ-3010

Synonyms

Coagulation factor II, F2, Prothrombin, PT, Thrombin



Technical Specifications

GeneID 2147
Species human
Expression HEK293
Activity N/A
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP00734
Molecular Mass 36 kDa, glycosylated
Formulation 20 mM MES pH 6.0 + 500 mM Choline Chloride, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage This protein is stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Repeated freeze thaw cycles should be avoided.
Reconstitution N/A

Background

Coagulation factors are a group of related proteins that are essential for normal blood clotting (haemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Prothrombin circulates in the bloodstream in an inactive form until an injury occurs. In response to that, prothrombin is converted to its active form, thrombin. Thrombin next converts a protein called fibrinogen into fibrin. Thrombin is also important for cell growth and division, tissue repair, and new blood vessels formation - angiogenesis (PMID: 11154146; 16549895; 15892853; 12421139).

Synonyms

Coagulation factor II, F2, Prothrombin, PT, Thrombin

Publications

SpeciesTitle
mouse

Clin Ther

A review of three stand-alone topical thrombins for surgical hemostasis.

Authors - Christine MCheng