Aggrecan Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 13880-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 39 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat, Zebrafish

Positive WB detected in:
ROS1728 cells

Positive IHC detected in:
human lung tissue, human cartilage tissue

Positive IF detected in:
A549 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
aggrecan

Calculated molecular weight:
250 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ACAN

Synonyms
ACAN, AGC1, AGCAN, aggrecan, CSPG1, CSPGCP, MSK16, SEDK
Background

Aggrecan (ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family (also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilaginous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site (PMID: 7852317; 9337874).


Back
to top