Bcl-XL Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66020-1-Ig |CloneNo.: 4C12A6

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells, A431 cells, HeLa cells, Jurkat cells

Positive IHC detected in:
human testis tissue, human colon tissue, human testis tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
Jurkat cells,

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-like 1

Calculated molecular weight:
26 kDa

Observed molecular weight:
30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCL2L1

Synonyms
Apoptosis regulator Bcl X, BCL2L1, Bcl-XL
Background

BCL2L1 is a member of he BCL-2 protein family. BCL2L1 is expressed as two distinct isoforms, Bcl-xL and Bcl-xS, and is located at the outer mitochondrial membrane. The Bcl-XL isoform is a 233 amino acid protein, acting as an apoptotic inhibitor. Bcl-XL can forms heterodimers with BAX, BAK or BCL2, and the heterodimerization with BAX does not seem to be required for anti-apoptotic activity. The Bcl-XS isoform is a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188), acting as an apoptotic activator.


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