Cyclin E2 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 11935-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human testis tissue, human breast cancer tissue, human testis tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclin E2

Calculated molecular weight:
374aa,44 kDa

Observed molecular weight:
44 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CCNE2

Synonyms
CCNE2, CYCE2, cyclin E2, G1/S specific cyclin E2
Background

Cyclin E2 (CCNE2) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of cyclindependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of cell cycle events. CCNE2 forms a complex with and functions as a regulatory subunit of CDK2 and has been shown to specifically interact with CIP/KIP family of CDK inhibitors. CCNE2 plays a role in cell cycle G1/S transition and its expression peaks at the G1-S phase. Whereas cyclin E1 is expressed in most proliferating normal and tumor cells, cyclin E2 levels are low or undetectable in nontransformed cells, and are elevated in tumor-derived cells.


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