IRF5 Antibody 15 Publications

Rabbit Polyclonal| Catalog number: 10547-1-AP

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Freight/Packing

Con: 26 μg/150 μl

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Species specificity:
human, mouse, rat, sheep

Positive WB detected in:
Jurkat cells, A549 cells, HeLa cells, human heart tissue, Jurkat cells, NIH/3T3 cells, SH-SY5Y cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interferon regulatory factor 5

Calculated molecular weight:
56 kDa

Observed molecular weight:
56 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IRF5

Synonyms
interferon regulatory factor 5, IRF 5, IRF5, SLEB10
Background

IRF5, also named as SLEB10, contians one IRF tryptophan pentad repeat DNA-binding domain and belongs to the IRF family. It is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. It is activated by TLR7 or TLR8 signaling. Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) and systemic lupus erythematosus type 10 (SLEB10). IRF5 is also used as M1 marcrophage lineage marker. Alternative splice variant encoding different isoforms exist. Catalog#10547-1-AP is a rabbit polyclonal antibody raised against the C-terminal of human IRF5.


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