JNK Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 24164-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, A431 cells, HeLa cells, Jurkat cells, NIH/3T3 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human cervical cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitogen-activated protein kinase 8

Calculated molecular weight:
48 kDa

Observed molecular weight:
44-48 kDa, 50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAPK8

Synonyms
c Jun N terminal kinase 1, JNK, JNK 46, JNK1, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MAPK8, PRKM8, SAPK1
Background

Three members of c-Jun N-terminal kinases (JNK), JNK1, JNK2 and JNK3, have been reported, which are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. JNK1 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun.


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