Cytokeratin 19 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 14965-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 64 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
MCF7 cells,HeLa cells, HepG2 cells, BxPC-3 cells

Positive IHC detected in:
human colon tissue,human liver cancer tissue, human skin cancer tissue, human pancreas cancer tissue, human thyroid cancer tissue, human breast cancer tissue, human lung cancer tissue, human urothelial carcinoma tissue, human prostate cancer tissue, human cervical cancer tissue

Positive IF detected in:
HeLa cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
keratin 19

Calculated molecular weight:
44 kDa

Observed molecular weight:
40 kDa, 46 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KRT19

Synonyms
CK 19, CK19, Cytokeratin 19, K19, K1CS, keratin 19, KRT19
Background

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT19, one of type I keratins, is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Due to its high sensitivity, KRT19 is the most used marker for detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. This antibody, generated against full length KRT19 protein, also recognizes KRT17, another type I keratin homologous to KRT19.


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