RBAP48 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66060-1-Ig |CloneNo.: 5C4D6

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 185 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human

Positive WB detected in:
Hepg2 cells, HEK-293 cells, HeLa cells

Positive IHC detected in:
human cervical cancer tissue, human cervical cancer tissue, human testis tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoblastoma binding protein 4

Calculated molecular weight:
48 kDa

Observed molecular weight:
53 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RBBP4

Synonyms
Histone binding protein RBBP4
Background

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This gene encodes a ubiquitously expressed nuclear protein that belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2/NuRD complex complex that has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of corepressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. A decrease of RbAp48 in the dentate gyrus (DG) of the hippocampus in the brain is suspected to be a main cause of memory loss in normal aging (PMID: 23986399).


Back
to top