SOX2 Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 11064-1-AP

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
Transfected HEK-293 cells

Positive IHC detected in:
human lung cancer tissue, mouse brain tissue, mouse embryo tissue

Positive IF detected in:
NCCIT cell, mouse embryo tissue, mouse olfactory epithelium tissue, Zebrafish

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:50-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
SRY (sex determining region Y)-box 2

Calculated molecular weight:
34 kDa

Observed molecular weight:
34 kDa-37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SOX2

Synonyms
ANOP3, MCOPS3, SOX2, Transcription factor SOX 2
Background

Sox2, also known as SRY (sex determining region Y)-box 2, is a transcription factor essential for maintaining self-renewal of undifferentiated ES cells and is one of the key transcription factors used to reprogram mouse and human fibroblasts to a pluripotent state. Sox2 expressed in undifferentiated pluripotent stem cells and germ cells during development. Affinity purified rabbit anti-Sox2 antibody can be used to demonstrate pluripotency of ES and iPS cells. This antibody is a rabbit polyclonal antibody raised against an internal region of human SOX2. a rare undiferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal diferentiation. Sox2-expressing neural stem cells in the subgranular zone (SGZ) , a well-known stem cell niche of the adult brain.


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