SURVIVIN Antibody 22 Publications

Rabbit Polyclonal| Catalog number: 10508-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 61 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells,A431 cells, PC-3 cells, NIH/3T3 cells, Jurkat cells, MCF-7 cells, A549 cells

Positive IP detected in:
U2OS cells, Jurkat cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human colon cancer tissue, human gliomas tissue, human lung cancer tissue, human pancreas cancer tissue, rat brain tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
baculoviral IAP repeat-containing 5

Calculated molecular weight:
16 kDa

Observed molecular weight:
16-18 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BIRC5

Synonyms
API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN
Background

Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.


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