WFS1 Antibody 24 Publications

Rabbit Polyclonal| Catalog number: 11558-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells, human heart tissue, human skeletal muscle tissue, mouse brain tissue, SH-SY5Y cells

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
mouse brain tissue, human ovary tumor tissue, human pancreas tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Wolfram syndrome 1 (wolframin)

Calculated molecular weight:
890aa,100 kDa

Observed molecular weight:
95-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
WFS1

Synonyms
FLJ51211, WFRS, WFS, WFS1, Wolfram syndrome 1 (wolframin), WOLFRAMIN
Background

Wolfram syndrome protein (WFS1), also called wolframin, is a transmembrane protein, which is located primarily in the endoplasmic reticulum and its expression is induced in response to ER stress, partially through transcriptional activation. ER localization suggests that WFS1 protein has physiological functions in membrane trafficking, secretion, processing and/or regulation of ER calcium homeostasis. It is ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations of the WFS1 gene are responsible for two hereditary diseases, autosomal recessive Wolfram syndrome and autosomal dominant low frequency sensorineural hearing loss.


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