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- KD/KO Validated
SLC30A8/ZNT8-Specific Polyclonal antibody
SLC30A8/ZNT8-Specific Polyclonal Antibody for IF, IHC, WB,ELISA
Cat no : 16169-1-AP
|Positive WB detected in||mouse pancreas tissue|
|Positive IHC detected in||human pancreas tissue, human pancreas cancer tissue, human liver cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||human pancreas tissue|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:250-1:1000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
16169-1-AP targets SLC30A8/ZNT8-Specific in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat, Yellow catfish|
|Host / Isotype||Rabbit / IgG|
|Full Name||solute carrier family 30 (zinc transporter), member 8|
|Calculated molecular weight||41 kDa|
|Observed molecular weight||45-50 kDa|
|GenBank accession number||NM_173851|
|Gene ID (NCBI)||169026|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
SLC30A8 (also named as ZNT8) encods the secretory granule zinc transporter, permiting cellular efflux of zinc. SLC30A8 was recently defined as a autoantigen candidates of type 2 diabetes, although the molecular mechanism through which this phenotype is manifest is incompletely understood.
|Product Specific Protocols|
|WB protocol for SLC30A8/ZNT8-Specific antibody 16169-1-AP||Download protocol|
|IHC protocol for SLC30A8/ZNT8-Specific antibody 16169-1-AP||Download protocol|
|IF protocol for SLC30A8/ZNT8-Specific antibody 16169-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Invest Ophthalmol Vis Sci
Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression.
Biochim Biophys Acta Gene Regul Mech
Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
J Biol Chem
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells.
J Biol Chem
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.
J Biol Chem
Lipid-tuned Zinc Transport Activity of Human ZnT8 Correlates with Risk for Type-2 Diabetes.