ubiquitin Antibody 21 Publications

Rabbit Polyclonal| Catalog number: 10201-2-AP

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Freight/Packing

Con: 26 μg/150 μl

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Species specificity:
human, mouse, rat, Arabidopsis thaliana, T. cruzi

Positive WB detected in:
MDA-MB-453s cells, HeLa cells, MCF-7 cells, MDA-MB-453s cells, mouse liver tissue

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human pancreas tissue, human ovary tumor tissue, human pancreas tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ubiquitin B

Calculated molecular weight:
26 kDa

Observed molecular weight:
8 kDa, 24 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
UBB

Synonyms
FLJ25987, Polyubiquitin B, UBB, ubiquitin, ubiquitin B
Background

Ubiquitin B (UBB) is a member of ubiquitin family, one of the most conserved proteins known. Ubiquitin B is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin B is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation.


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