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Recombinant Human LAIR2 protein (rFc Tag) (HPLC verified)

Species

Human

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg4247

Validation Data Gallery

  • Purity of Recombinant Human LAIR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human LAIR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human LAIR2 was greater than 90% as determined by SEC-HPLC.

    The purity of Human LAIR2 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human LAIR2 protein Gln22-Pro152 (Accession# Q6ISS4-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 3904
Accession Q6ISS4-1
PredictedSize 40.3 kDa
SDS-PAGE 42-50 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

LAIR2, or leukocyte-associated immunoglobulin-like receptor 2, is a protein that belongs to the immunoglobulin superfamily. It is highly expressed in the placenta, specifically in the extravillous trophoblasts (EVTs) at the leading edge of the anchoring cell columns invading the maternal decidua. LAIR2 expression has also been noted to be down-regulated in the first trimester of pregnancies destined for preeclampsia, suggesting a potential role in the etiology of this condition. LAIR2 has been implicated in cancer immunotherapy. A study suggests that LAIR-2 can act as a decoy receptor by binding collagen with higher affinity than LAIR-1, potentially releasing LAIR-1-mediated immune suppression. This could be a novel strategy for cancer immunotherapy, particularly for immune-excluded tumors.

References:

1. Founds SA. et al. (2013) Placenta. 34(3):248-55.
2. Ramos MIP. et al. (2021) Elife. 10:e62927.
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