Recombinant Human MUC13 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6586
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human MUC13 protein Thr19-Leu421 (Accession# Q9H3R2) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 56667 |
| Accession | Q9H3R2 |
| PredictedSize | 68.2 kDa |
| SDS-PAGE | 88-95 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Mucins (MUC) are highly glycosylated proteins that are abundantly expressed in mammalian epithelial cells. Mucin 13 (MUC13) is a member of the transmembrane glycoprotein mucins, which are normally expressed in the large intestine, trachea, kidney, small intestine, and gastric epithelium. MUC13 is involved in the tumorigenesis of multiple malignancies, including pancreatic cancer, colorectal cancer, renal cancer, and lung cancer.
References:
1. Chauhan, Subhash C et al.Mol Cancer Ther. vol. 11,1 (2012): 24-33. 2. Pang, Yao et al. Oncology letters vol. 23,1 (2022): 37. 3. Sheng, Yong Hua et al. Oncogene vol. 38,48 (2019): 7294-7310.