CoraLite®488-conjugated BRE Monoclonal antibody

BRE Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG2a

Reactivity

human, rat, mouse

Applications

IF

Conjugate

CoraLite®488 Fluorescent Dye

CloneNo.

2E5A5

Cat no : CL488-66356

Synonyms

BRCA1 A complex subunit BRE, BRCC4, BRCC45, BRE



Tested Applications

Positive IF detected inmouse brain tissue
For other applications, we recommend the unconjugated version of this antibody, 66356-1-Ig

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

CL488-66356 targets BRE in IF applications and shows reactivity with human, rat, mouse samples.

Tested Reactivity human, rat, mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen BRE fusion protein Ag2256
Full Name brain and reproductive organ-expressed (TNFRSF1A modulator)
Calculated molecular weight 383 aa, 44 kDa
Observed molecular weight 42-47 kDa
GenBank accession numberBC001251
Gene symbol BRE
Gene ID (NCBI) 9577
Conjugate CoraLite®488 Fluorescent Dye
Excitation/Emission maxima wavelengths488 nm/515 nm
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

Background Information

BRE, also named as BRCC45, is a death receptor-associated antiapoptotic protein, which is also involved in DNA-damage repair, and K63-specific deubiquitination. BRE and its XIAP-sustaining mechanism could represent novel targets for anti-cancer therapy. BRE may regulate TNF-alpha signaling through its interactions with TNFRSF1A. It plays a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE gene has four isoforms with MW 42-47 kDa.

Protocols

Product Specific Protocols
IF protocol for CL488 BRE antibody CL488-66356Download protocol
Standard Protocols
Click here to view our Standard Protocols