Product Information
25146-1-PBS targets Cathepsin E in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag18484 Product name: Recombinant human CTSE protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 108-275 aa of BC042537 Sequence: YCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEG Predict reactive species |
| Full Name | cathepsin E |
| Calculated Molecular Weight | 396 aa, 43 kDa |
| Observed Molecular Weight | 43-48 kDa |
| GenBank Accession Number | BC042537 |
| Gene Symbol | CTSE |
| Gene ID (NCBI) | 1510 |
| RRID | AB_3742138 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P14091 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Cathepsin E (CTSE) is an aspartic protease and a member of the peptidase A1 family of proteases, along with pepsin A and cathepsin D (CTSD) (PMID: 31582345). Caathepsin E is essential for degradation of these lysosomal membrane proteins, and that its deficiency is implicated in the development of a new form of lysosomal storage disorder associated with the elevation of lysosomal pH (PMID: 17095504). It associates with lysosomal and endosomal pathways participating actively in immune response regulation. Cathepsin E specifically induces growth arrest and apoptosis in human prostate cancer cell lines (PMID: 20482316).
